REVOLUCIJA U BUDUĆNOSTI KOD OTKRIĆA NOVIH LEKOVA: UPOTREBA VEŠTAČKE INTELIGENCIJE OD STRANE INDUSTRIJSKIH DIVOVA I STUDIJA SLUČAJA KOMPANIJE
DOI:
https://doi.org/10.56362/Rev23101011SKljučne reči:
veštačka inteligencija u otkrivanju lekova, farmaceutska industrija, identifikacija mete u veštačkoj inteligenciji, skrining lekova, optimizacija kliničkih ispitivanjaApstrakt
Veštačka inteligencija (AI) je revolucionarno uticala na proces otkrivanja lekova omogućavajući istraživačima da analiziraju ogromne količine podataka i generišu uvide koje bi ljudima bilo teško da identifikuju. AI se koristi u različitim aplikacijama kao što su identifikacija cilja, skrining lekova, optimizacija lekova i dizajn i izvođenje kliničkih ispitivanja. To je dovelo do razvoja efikasnijih lekova i boljih ishoda za pacijente. Očekuje se da će se upotreba veštačke inteligencije u otkrivanju lekova povećati u narednim godinama. U ovom radu je data analiza 27 farmaceutskih giganata, zajedno sa studijom slučaja kompanije Abbvie Inc. o njihovoj upotrebi veštač- ke inteligencije u farmaceutskoj industriji.
Reference
Berg Health. (n.d.). Clinical trial A.I. Accessed March 12, 2023, https://berghealth.com/clinical-trial-ai/; BenevolentAI. (n.d.). Another discovery. Accessed March 12, 2023. https://www.benevolent.com/approach/drug-discovery.
Exscientia. (n.d.). Another discovery. Accessed March 12, 2023. https://www.exscientia.ai/drug-discovery/
Insilico Medicine. (n.d.). Another discovery. Retrieved March 12, 2023, from https://insilico.com/drug-discovery; Mendel.ai. (n.d.). Accelerating clinical trials with A.I. Accessed March 12, 2023, from https://www.mendel.ai/solutions/clinical-trials.
Forbes. (2021). The World’s Largest Public Companies. Pharmaceutical & Biotech Industry. Forbes Global 2000. Accessed March 13, 2023. https://www.forbes.com/global2000/list/#header:pharma-biotech.
Duch, W. et al. (2007) Artificial intelligence approaches for rational drug design and discovery. Curr. Pharm. Des. 13, 1497–1508.
Henstock, P. Artificial intelligence for Pharma: Time for internal investment. Trends in Pharmacological Sciences, August 2019, Vol. 40, No. 8.
Alsevar, J. Medicine by Machine. Fortune. February 2020.
DiMasi, J.A. et al. (2016) Innovation in the pharmaceutical industry: new estimates of R&D costs. J. Health Econ. 47, 20–33.
Lamberti, M. et al. A Study on the Application and Use of Artificial. Intelligence to Support Drug Development. 2019 Elsevier.
Lamberti, M. et al. A Study on the Application and Use of Artificial. Intelligence to Support Drug Development. 2019 Elsevier.
Ranganathan, A., & Ong, W.K. (2020). The Role of Artificial Intelligence in Drug Discovery. Clinical and Translational Medicine, 10(4), e186. https://doi.org/10.1002/ctm2.186 ; Aspuru-Guzik, A. (2021). Artificial intelligence and the future of drug discovery. Journal of Medicinal Chemistry, 64(14), 9075-9076. https://doi.org/10.1021/acs.jmedchem.1c01080; Ma, J., Sheridan, R.P., Liaw, A., Dahl, G.E., Svetnik, V., & DeepChem Development Team. (2019). Deep learning enables rapid identification of potent DDR1 kinase inhibitors. Nature Biotechnology, 37(9), 1038-1040. https://doi.org/10.1038/s41587-019-0224-x
Stamenovic, M. Data analysed and provided as source for the table by the author.
About AbbVie. AbbVie. Accessed March 13, 2023. https://www.abbvie.com/about-us/overview.html.
Abbvie Reports Fourth-Quarter and Full-Year 2020 Financial Results.” AbbVie. Accessed March 13, 2023. https://www.abbvie.com/newsroom/news/abbvie-reports-fourth-quarter-and-full-year-2020-financial-results.html.
AbbVie. (2022, February 4). AbbVie Reports Full-Year and Fourth-Quarter 2021 Financial Results (Press release). https://news.abbvie.com/news/press-releases/abbvie-reports-full-year-and-fourth-quarter-2021-financial-results.htm
Insilico Medicine and AbbVie collaborate to accelerate drug discovery for age-related diseases.” Insilico Medicine. Accessed March 13, 2023. https://insilico.com/press-releases/insilico-medicine-and-abbvie-collaborate-to-accelerate-drug-discovery-for-age-related-diseases.
A.I. specialist Cyclica partners with AbbVie on drug discovery.” PMLive. Accessed March 13, 2023. https://www.pmlive.com/pharma_news/ai_specialist_cyclica_partners_with_abbvie_on_drug_discovery_1297745. AbbVie and Biocorpora sign drug discovery collaboration. European Pharmaceutical Review. Accessed March 13, 2023. https://www.europeanpharmaceuticalreview.com/news/121633/abbvie-and-biocorpora-sign-drug-discovery-collaboration/
